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https://hdl.handle.net/2440/77218
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Type: | Journal article |
Title: | Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: temporal trends and timing of amniocentesis in pregnancy |
Author: | Jensen, M. Norgaard-Pedersen, B. Toft, G. Hougaard, D. Bonde, J. Cohen, A. Thulstrup, A. Ivell, R. Anand Ivell, R. Lindh, C. Jonsson, B. |
Citation: | Environmental Health Perspectives, 2012; 120(6):897-903 |
Publisher: | U.S. Dept of Health and Human Services Public Health Science |
Issue Date: | 2012 |
ISSN: | 0091-6765 1552-9924 |
Statement of Responsibility: | Morten Søndergaard Jensen, Bent Nørgaard-Pedersen, Gunnar Toft, David M. Hougaard, Jens Peter Bonde, Arieh Cohen, Anne Marie Thulstrup, Richard Ivell, Ravinder Anand-Ivell, Christian H. Lindh and Bo A.G. Jönsson |
Abstract: | BACKGROUND: Measures of prenatal environmental exposures are important, and amniotic fluid levels may directly reflect fetal exposures during hypothesized windows of vulnerability. OBJECTIVES: We aimed to detect various phthalate metabolites and perfluorooctanesulfonic acid (PFOS) in human amniotic fluid, to study temporal exposure trends, and to estimate potential associations with gestational week of amniocentesis and maternal age and parity at amniocentesis. METHODS: We studied 300 randomly selected second-trimester amniotic fluid samples from a Danish pregnancy-screening biobank covering 1980 through 1996. We used only samples from male offspring pregnancies. We assayed the environmental pollutants by liquid chromatography/triple quadrupole mass spectrometry and analyzed data using generalized linear regression models. RESULTS: We detected the di(2-ethylhexyl) phthalate (DEHP) metabolite mono(2-ethyl-5-carboxypentyl) phthalate (5cx-MEPP) at a median concentration of 0.27 ng/mL [interquartile range (IQR): 0.20–0.37 ng/mL], the diisononyl phthalate (DiNP) metabolite mono(4-methyl-7-carboxyheptyl) phthalate (7cx-MMeHP) at 0.07 ng/mL (IQR: 0.05–0.11 ng/mL), and PFOS at 1.1 ng/mL (IQR: 0.66–1.60 ng/mL). An increase of 1 calendar year was associated with 3.5% lower [95% confidence interval (CI): –4.8%, –2.1%] 5cx-MEPP levels and with 7.1% higher (95% CI: 5.3%, 9.0%) 7cx-MMeHP levels. For each later gestational week of amniocentesis, 5cx-MEPP was 9.9% higher (95% CI: 4.8%, 15.2%), 7cx-MMeHP was 8.6% higher (95: CI: 2.7%, 14.9%), and PFOS was 9.4% higher (95: CI: 3.3%, 15.9%). We observed no associations with maternal age or parity. CONCLUSIONS: Measured metabolite levels appeared to parallel decreasing DEHP exposure and increasing DiNP exposure during the study period. The environmental pollutant levels were positively associated with later gestational age at amniocentesis during pregnancy weeks 12–22. |
Keywords: | Amniocentesis amniotic fluid biobank biomonitoring perfluorinated compounds phthalates pregnancy temporal trend |
Rights: | Publication of EHP lies in the public domain and therefore is without copyright. All text from EHP may be reprinted freely. |
DOI: | 10.1289/ehp.1104522 |
Published version: | http://dx.doi.org/10.1289/ehp.1104522 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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hdl_77218.pdf | Published version | 391.75 kB | Adobe PDF | View/Open |
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