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https://hdl.handle.net/2440/7770
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Type: | Journal article |
Title: | GM-CSF-induced priming of human neutrophils for enhanced phagocytosis and killing of asexual blood stages of Plasmodium falciparum: synergistic effects of GM-CSF and TNF |
Author: | Kumaratilake, L. Ferrante, A. Jaeger, T. Rzepczyk, C. |
Citation: | Parasite Immunology, 1996; 18(3):115-123 |
Publisher: | Blackwell Science |
Issue Date: | 1996 |
ISSN: | 0141-9838 1365-3024 |
Statement of Responsibility: | Lakshmi M. Kumaratilake, Antonio Ferrante, Timothy Jaeger & Christine Rzepczyk |
Abstract: | Granulocyte macrophage-colony stimulation factor (GM-CSF), which is a haematopoietic cytokine generated by activated T lymphocytes and macrophages during infection, was investigated for its effects on human neutrophil-mediated killing of asexual blood forms of Plasmodium falciparum. Pretreatment of neutrophils with human recombinant-GM-CSF markedly increased the parasite killing (measured by a radiometric assay), in the presence of normal serum (containing complement), immune serum (IS), purified IgG (from IS) or heat inactivated IS. GM-CSF pretreatment also enhanced phagocytosis of the parasite by neutrophils and the expression of CR3, FcγRII and FcγRIII receptors. Treatment of neutrophils with a combination of GM-CSF and TNF resulted in a synergistic increase in phagocytosis and killing of the parasite. The findings suggest that GM-CSF is likely to form part of the cytokine network responsible for regulating the antiparasitic activity of the neutrophil in malaria. |
Keywords: | Malaria; neutrophils; phagocytosis; GM-CSF; TNF |
Description: | Article first published online: 31 OCT 2003 |
Rights: | © 1996 Blackwell Science Ltd. |
DOI: | 10.1046/j.1365-3024.1996.d01-64.x |
Published version: | http://dx.doi.org/10.1046/j.1365-3024.1996.d01-64.x |
Appears in Collections: | Aurora harvest Paediatrics publications |
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