Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/78326
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Evolutionary conservation and functional roles of ncRNA |
Author: | Qu, Z. Adelson, D. |
Citation: | Frontiers in Genetics, 2012; 3(205):1-11 |
Publisher: | Frontiers Research Foundation |
Issue Date: | 2012 |
ISSN: | 1664-8021 1664-8021 |
Statement of Responsibility: | Zhipeng Qu and David L. Adelson |
Abstract: | Non-coding RNAs(ncRNAs)are a class of transcribed RNA molecules without protein-coding potential. They were regarded as transcriptional noise,or the by product of genetic information flow from DNA to protein for a long time. However, in recent years, a number of studies have shown that ncRNAs are pervasively transcribed, and most of them show evidence of evolutionary conservation, although less conserved than protein-coding genes. More importantly, many ncRNAs have been confirmed as playing crucial regulatory roles in diverse biological processes and tumorigenesis. Here we summarize the functional significance of this class of “darkmatter” in terms its genomic organization,evolutionary conservation, and broad functional classes. |
Keywords: | ncRNA transcription genetic long ncRNA evolution molecular gene regulation |
Description: | Extent: 11 p. |
Rights: | Copyright: © 2012 Qu and Adelson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
DOI: | 10.3389/fgene.2012.00205 |
Published version: | http://dx.doi.org/10.3389/fgene.2012.00205 |
Appears in Collections: | Aurora harvest 4 Environment Institute publications Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_78326.pdf | Published version | 708.72 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.