Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7857
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Site-specific changes in transforming growth factor-α and -β1 expression in colonic mucosa of adolescents with inflammatory bowel disease |
Other Titles: | Site-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease |
Author: | Xian, C. Xu, X. Mardell, C. Howarth, G. Byard, R. Moore, D. Miettinen, P. Read, L. |
Citation: | Scandinavian Journal of Gastroenterology, 1999; 34(6):591-600 |
Publisher: | Informa |
Issue Date: | 1999 |
ISSN: | 0036-5521 1502-7708 |
Statement of Responsibility: | C. J. Xian, X. Xu, C. E. Mardell, G. S. Howarth, R. W. Byard, D. J. Moore, P. Miettinen & L. C. Read |
Abstract: | <h4>Background</h4>Transforming growth factors (TGF-alpha and -beta1) play important roles in intestinal growth and repair. To further understand their roles in the pathophysiology of inflammatory bowel disease (IBD), this study examined changes in their expression in colonic mucosa of adolescents with IBD.<h4>Methods</h4>TGF-alpha and -beta1 expression was examined by immunohistochemistry and in situ hybridization.<h4>Results</h4>TGF-gamma immunostaining and mRNA labelling appeared unchanged in the epithelium of specimens with active IBD. Similarly, expression of epithelial TGF-beta1 remained unaltered in IBD. However, the numbers of TGF-beta1-positive cells, including T cells, neutrophils, and monocytes/macrophages, in the lamina propria increased during disease activity.<h4>Conclusions</h4>Adolescent IBD is characterized by a normal expression of TGF-alpha and -beta1 peptide and mRNA in the colonic epithelium but by an increased density of TGF-beta1-positive immune cells in the lamina propria during disease activity, suggesting a role in inflammatory modulation in IBD. |
Keywords: | Adolescent Crohn disease immunohistochemistry inflammatory bowel disease in situ hybridization transforming growth factor-a transforming growth factor-b ulcerative colitis |
Rights: | © Scandinavian University Press 1999 |
DOI: | 10.1080/003655299750026056 |
Published version: | http://dx.doi.org/10.1080/003655299750026056 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.