Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/80095
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Type: | Journal article |
Title: | Omega-6 polyunsaturated fatty acids and the early origins of obesity |
Author: | Muhlhausler, B. Ailhaud, G. |
Citation: | Current Opinion in Endocrinology, Diabetes and Obesity, 2013; 20(1):56-61 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2013 |
ISSN: | 1752-296X 1752-2978 |
Statement of Responsibility: | Beverly S. Muhlhausler and Gérard P. Ailhaud |
Abstract: | PURPOSE OF REVIEW: The incidence of obesity and its related metabolic disorders has increased significantly over the past 3 decades, culminating in the current global epidemic of metabolic disease and leading to the search for contributing factors. Exposure of the developing foetus/neonate to a typical Western diet increases their risk of obesity and metabolic disorders throughout the life-course, creating an intergenerational cycle of metabolic disease. In Western countries, this epidemic of metabolic disease has coincided with a marked increase in the intake of omega-6 polyunsaturated fatty acids (omega-6 PUFA), leading to suggestions that the two may be causally related. RECENT FINDINGS: Recent studies have emphasized the proadipogenic properties of the omega-6 PUFA, and provided evidence that rodents fed on diets with omega-6 PUFA contents similar to the typical US diet (6–8% energy) have an increased fat mass. Importantly, recent studies have shown that perinatal exposure to a high omega-6 PUFA diet results in a progressive accumulation of body fat across generations. SUMMARY: This review highlights the recent evidence supporting the role of the omega-6 PUFA in the early life origins of obesity and metabolic disease, the need for more clinical studies and the potential need for health agencies to re-evaluate current recommendations to further increase omega-6 PUFA intakes. |
Keywords: | Humans Prenatal Exposure Delayed Effects Obesity Fatty Acids, Omega-6 Diet Pregnancy Adult Child, Preschool Infant Infant, Newborn Female Male Maternal Nutritional Physiological Phenomena |
Rights: | Copyright: © 2013 Wolters Kluwer Health |
DOI: | 10.1097/MED.0b013e32835c1ba7 |
Published version: | http://dx.doi.org/10.1097/med.0b013e32835c1ba7 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 4 |
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hdl_80095.pdf | Accepted version | 555.36 kB | Adobe PDF | View/Open |
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