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https://hdl.handle.net/2440/81509
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dc.contributor.author | Mendes, R. | - |
dc.contributor.author | Mendoza, M. | - |
dc.contributor.author | Banga Singh, K. | - |
dc.contributor.author | Castanheira, M. | - |
dc.contributor.author | Bell, J. | - |
dc.contributor.author | Turnidge, J. | - |
dc.contributor.author | Lin, S. | - |
dc.contributor.author | Jones, R. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy, 2013; 57(11):5721-5726 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.issn | 1098-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2440/81509 | - |
dc.description.abstract | The Regional Resistance Surveillance program monitored susceptibility rates and developing resistance by geographic region, including 12 Asia-Pacific (APAC) countries. Reference broth microdilution methods for susceptibility/interpretations were applied, processing 5,053 strains. Among Staphylococcus aureus isolates (37% methicillin-resistant S. aureus [MRSA], highest in South Korea [73%]), linezolid (LZD), tigecycline (TIG), and vancomycin were 100% active, but 33 and 34% of strains were levofloxacin (LEV) or macrolide resistant, respectively. Streptococcus pneumoniae was most resistant to β-lactams and macrolides (45%) but was LZD, LEV, and TIG susceptible (>98%). Extended-spectrum β-lactamase (ESBL) phenotype rates in Escherichia coli and Klebsiella spp. were 48 and 47%, respectively, and were highest in Taiwan, at 75 to 91%. The best anti-ESBL-phenotype agents were amikacin (81 to 96% susceptible), colistin (COL; >98%), TIG (>98%), and carbapenems (81 to 97%). Pseudomonas aeruginosa showed ≥20% resistance to all drugs except COL (99% susceptible). In conclusion, endemic evolving antimicrobial resistances in APAC nations show compromised roles for many commonly used antimicrobials. | - |
dc.description.statementofresponsibility | Rodrigo E. Mendes, Myrna Mendoza, Kirnpal K. Banga Singh, Mariana Castanheira, Jan M. Bell, John D. Turnidge, Stephen S. F. Lin, Ronald N. Jones | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Microbiology | - |
dc.rights | Copyright © 2013, American Society for Microbiology. All Rights Reserved. | - |
dc.source.uri | http://dx.doi.org/10.1128/aac.01121-13 | - |
dc.subject | Humans | - |
dc.subject | Pseudomonas aeruginosa | - |
dc.subject | Escherichia coli | - |
dc.subject | Klebsiella | - |
dc.subject | Staphylococcus aureus | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Gram-Negative Bacterial Infections | - |
dc.subject | Gram-Positive Bacterial Infections | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Microbial Sensitivity Tests | - |
dc.subject | Drug Resistance, Multiple, Bacterial | - |
dc.subject | Asia | - |
dc.subject | Australia | - |
dc.subject | New Zealand | - |
dc.subject | Epidemiological Monitoring | - |
dc.title | Regional resistance surveillance program results for 12 Asia-Pacific nations (2011) | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1128/AAC.01121-13 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Turnidge, J. [0000-0003-4240-5578] | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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