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https://hdl.handle.net/2440/82052
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Type: | Journal article |
Title: | Pattern of cerebrospinal immediate early gene c-fos expression in an ovine model of non-accidental head injury |
Author: | Finnie, J. Blumbergs, P. Manavis, J. Vink, R. |
Citation: | Journal of Clinical Neuroscience, 2013; 20(12):1759-1761 |
Publisher: | Churchill Livingstone |
Issue Date: | 2013 |
ISSN: | 0967-5868 1532-2653 |
Statement of Responsibility: | J.W. Finnie, P.C. Blumbergs, J. Manavis, R. Vink |
Abstract: | Expression of the immediate early gene, c-fos, was examined in a large animal model of non-accidental head injury ("shaken baby syndrome"). Lambs were used because they have a relatively large gyrencephalic brain and weak neck muscles resembling a human infant. Neonatal lambs were manually shaken in a manner similar to that believed to occur with most abused human infants, but there was no head impact. The most striking c-fos expression was in meningothelial cells of the cranial cervical spinal cord and, to a lesser degree, in hemispheric, cerebellar, and brainstem meninges. Vascular endothelial cells also frequently showed c-fos immunopositivity in the meninges and hemispheric white matter. It was hypothesised that this c-fos immunoreactivity was due to mechanical stress induced by shaking, with differential movement of different craniospinal components. |
Keywords: | Animal model c-fos expression Non-accidental head injury |
Rights: | Crown copyright © 2013 |
DOI: | 10.1016/j.jocn.2013.03.010 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1016/j.jocn.2013.03.010 |
Appears in Collections: | Aurora harvest 4 Medical Sciences publications |
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