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https://hdl.handle.net/2440/8342
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Type: | Journal article |
Title: | Reduction of ovulation rate in the rat by administration of a neutrophil-depleting monoclonal antibody |
Author: | Brannstrom, M. Bonello, N. Norman, R. Robertson, S. |
Citation: | Journal of Reproductive Immunology, 1995; 29(3):265-270 |
Publisher: | Elsevier Biomedical Press |
Issue Date: | 1995 |
ISSN: | 0165-0378 1872-7603 |
Abstract: | To investigate the effect of systemic neutrophil depletion on ovulation rate, rats were synchronised with eCG and hCG, and concurrently were administered neutrophil-specific, cytotoxic RP-3 monoclonal antibody (mAb), or an irrelevant, class-matched mAb. Neutrophils in the peripheral blood and in the thecal-luteal area of corpora lutea were detected by immunohistochemical analysis with the neutrophil-specific mAb MCA149 and were found to be reduced in number by 70% and 38% respectively following RP-3 treatment compared to the control group. Ovulation rate, as assessed by counting the number of oocytes in the ampullary region of the oviduct 20 h after hCG administration, was found to be reduced by 27% in the neutrophil-depleted rats. This result provides further evidence that neutrophilic granulocytes play an active role in ovulation in the rat. |
Keywords: | Neutrophils Animals Rats Rats, Sprague-Dawley Antibodies, Monoclonal Ovulation Female |
DOI: | 10.1016/0165-0378(95)00941-D |
Published version: | http://dx.doi.org/10.1016/0165-0378(95)00941-d |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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