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https://hdl.handle.net/2440/8351
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Type: | Journal article |
Title: | Surgically obtained sperm, and risk of gestational hypertension and pre-eclampsia |
Author: | Wang, X. Knottnerus, A. Schuit, G. Norman, R. Chan, A. Dekker, G. |
Citation: | The Lancet, 2002; 359(9307):673-674 |
Publisher: | Lancet Ltd |
Issue Date: | 2002 |
ISSN: | 0140-6736 1474-547X |
Statement of Responsibility: | Jim X Wang, Anne-Margreet Knottnerus, Giny Schuit, Robert J Norman, Annabelle Chan and Gus A Dekker |
Abstract: | The cause of pre-eclampsia is unknown, although a partner-specific immune maladaptation might be involved. We compared rates of pre-eclampsia and gestational hypertension in women whose genital tracts had and had not been exposed to their partner's sperm cells. Our aim was to ascertain whether or not protective partner-specific immune-tolerance is conveyed by sperm cells, rather than seminal fluid. Our findings indicate that, compared with women exposed to their partner's sperm cells and seminal fluid—ie, those treated with in-vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) with ejaculated sperm—the risk of hypertension was doubled and the risk of pre-eclampsia tripled in those never exposed to their partner's sperm—ie, those treated with ICSI done with surgically obtained sperm. |
Keywords: | Spermatozoa Semen Humans Pre-Eclampsia Hypertension Fertilization in Vitro Sperm Injections, Intracytoplasmic Logistic Models Immune Tolerance Pregnancy Female Male |
DOI: | 10.1016/S0140-6736(02)07804-2 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/31066/description#description |
Published version: | http://dx.doi.org/10.1016/s0140-6736(02)07804-2 |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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