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https://hdl.handle.net/2440/8414
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Type: | Journal article |
Title: | Prenatal exposure to SKF-38393 alters the response to light of adult rats |
Author: | Ferguson, S. Kennaway, D. |
Citation: | NeuroReport, 2000; 11(7):1539-1541 |
Publisher: | Lippincott, Williams & Wilkins |
Issue Date: | 2000 |
ISSN: | 0959-4965 1473-558X |
Statement of Responsibility: | Sally A. Ferguson and David J. Kennaway |
Abstract: | The current study examined the consequences of prenatal SKF-38393 exposure on the cellular response in the adult suprachiasmatic nuclei to light. Pregnant rats were injected with the dopamine agonist SKF-38393 or vehicle daily from gestational day 15 to 21. Adult offspring received a light pulse (1 min/2 lux) 4 or 8 h after lights off (ZT16 or ZT20 where ZT = zeitgeber time). Brains were processed for c-FOS-like immunoreactivity in the SCN. At ZT20 the number of cells expressing c-FOS protein after a light pulse was the same in both groups. At ZT16 the number of cells in the SCN of SKF-38393-exposed animals was 58% lower than the vehicle-treated group. The data suggest that prenatal SKF-38393 treatment may have long-term consequences for SCN function. |
Keywords: | c-fos Circadian rhythm Development Dopamine Suprachiasmatic nucleus |
Rights: | © 2000 Lippincott Williams & Wilkins |
DOI: | 10.1097/00001756-200005150-00035 |
Published version: | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200005150-00034&LSLINK=80&D=ovft |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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