Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/85721
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Type: | Journal article |
Title: | Prediction of fetal lung immaturity using gestational age, patient characteristics and fetal lung maturity tests: a probabilistic approach |
Author: | Wijnberger, L. de Kleine, M. Voorbij, H. Arabin, B. Bruinse, H. Visser, G. Bossuyt, P. Mol, B. |
Citation: | Archives of Gynecology and Obstetrics, 2010; 281(1):15-21 |
Publisher: | Springer-Verlag |
Issue Date: | 2010 |
ISSN: | 0932-0067 1432-0711 |
Statement of Responsibility: | L. D. E. Wijnberger, M. de Kleine, H. A. M. Voorbij, B. Arabin, H. W. Bruinse, G. H. A. Visser, P. M. M. Bossuyt, B. W. J. Mol |
Abstract: | Objectives: The lecithin/sphingomyelin (L/S) ratio and the lamellar body count (LBC) can be used to predict respiratory distress syndrome (RDS). Design: We performed a retrospective cohort study among consecutive women who underwent amniotic fluid sampling for the assessment of fetal lung maturity. Logistic regression was used to construct models for the prediction of RDS in three gestational age categories, with models based on clinical characteristics only, clinical characteristics and the LBC, and on clinical characteristics and L/S ratio. Results: When amniotic fluid was collected <30 weeks, the specificity of the LBC was 30% and the sensitivity 100%. Addition of the L/S ratio increased the specifity to 60%, for a sensitivity of 100%. When amniocentesis was performed between 30 and 33 weeks, addition of the L/S ratio only marginally improved the performance of the LBC. Conclusions: At a gestational age <30 weeks, the L/S ratio has additional value over the LBC. Above 30 weeks of gestation, single use of the LBC seems sufficient. |
Keywords: | Fetal lung maturity; Lamellar body count; L/S ratio; Respiratory distress sydrome (RDS) |
Rights: | © The Author(s) 2009. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
DOI: | 10.1007/s00404-009-1033-0 |
Published version: | http://dx.doi.org/10.1007/s00404-009-1033-0 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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hdl_85721.pdf | Published version | 359.01 kB | Adobe PDF | View/Open |
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