Adelaide Research & Scholarship
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https://hdl.handle.net/2440/8708
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| Type: | Journal article |
| Title: | The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis. |
| Author: | Brown, Matthew A. Rudwaleit, M. Pile, Kevin D. Kennedy, L. Gail Shatford, Jane L. Amos, Christopher I. Siminovitch, K. Rubin, L. Calin, Andrei Wordsworth, B. Paul |
| Citation: | British Journal of Rheumatology. 37(4):454-458 |
| Issue Date: | 1998 |
| Statement of Responsibility: | M. A. Brown, M. Rudwaleit, K. D. Pile, L. G. Kennedy, J. Shatford, C. I. Amos, K. Siminovitch, L. Rubin, A. Calin and B. P. Wordsworth |
| Abstract: | The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda > or = 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis. |
| DOI: | 10.1093/rheumatology/37.4.454 |
| Appears in Collections: | Medicine publications |
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