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https://hdl.handle.net/2440/87321
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Type: | Journal article |
Title: | Restricted Semliki Forest virus replication in communication perforin and Fas-ligand double-deficient mice |
Author: | Alsharifi, M. Lobigs, M. Bettadapura, J. Koskinen, A. Mullbacher, A. |
Citation: | Journal of General Virology, 2008; 89(8):1942-1944 |
Publisher: | Society for General Microbiology |
Issue Date: | 2008 |
ISSN: | 0022-1317 1465-2099 |
Statement of Responsibility: | Mohammed Alsharifi, Mario Lobigs, Jayaram Bettadapura, Aulikki Koskinen and Arno Müllbacher |
Abstract: | Previously, we have shown that mice defective in granule exocytosis and/or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf−/−xgld) relative to that in wild-type counterparts and found that viral replication in perf−/−xgld mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated. |
Keywords: | Animals Mice, Inbred C57BL Mice, Knockout Mice Semliki forest virus Alphavirus Infections Virus Replication Organ Specificity Fas Ligand Protein Perforin |
Rights: | © 2008 SGM |
DOI: | 10.1099/vir.0.83626-0 |
Published version: | http://dx.doi.org/10.1099/vir.0.83626-0 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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