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https://hdl.handle.net/2440/8816
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dc.contributor.author | Willoughby, S. | - |
dc.contributor.author | Chirkov, Y. | - |
dc.contributor.author | Kennedy, J. | - |
dc.contributor.author | Murphy, G. | - |
dc.contributor.author | Chirkova, L. | - |
dc.contributor.author | Horowitz, J. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | European Journal of Pharmacology, 1998; 356(2-3):207-213 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8816 | - |
dc.description.abstract | A number of anti-anginal agents (perhexiline, amiodarone, trimetazidine) have been shown to inhibit myocardial carnitine palmitoyltransferase-1, which controls access of long-chain fatty acids to mitochondrial sites of beta-oxidation. In view of clinical data suggesting that perhexiline improves symptomatic status in unstable angina pectoris, and the known role of mitochondrial beta-oxidation in platelet metabolism, we compared the platelet carnitine palmitoyltransferase-1 inhibitory and putative anti-aggregatory effects of perhexiline, amiodarone and trimetazidine with those of specific carnitine palmitoyltransferase-1 inhibitors: etomoxir and hydroxyphenylglyoxylate in both normal subjects and patients with stable angina. All of the compounds examined inhibited platelet carnitine palmitoyltransferase-1 activity; rank order of potency etomoxir > malonyl-CoA > hydroxyphenylglyoxylate > amiodarone > or = perhexiline > trimetazidine. However, only perhexiline, amiodarone and trimetazidine inhibited platelet aggregation. We conclude that (a) the carnitine palmitoyltransferase-1 inhibitors perhexiline, amiodarone and trimetazidine exert significant anti-aggregatory effects which may be therapeutically relevant and, (b) these effects are independent of carnitine palmitoyltransferase-1 inhibition. | - |
dc.description.statementofresponsibility | Scott R. Willoughby, Yuliy Y. Chirkov, Jennifer A. Kennedy, Geraldine A. Murphy, Larissa P. Chirkova, John D. Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | Copyright © 1998 Elsevier Science B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/s0014-2999(98)00527-5 | - |
dc.subject | Perhexiline | - |
dc.subject | Amiodarone | - |
dc.subject | Trimetazidine | - |
dc.subject | Platelet aggregation | - |
dc.subject | Carnitine palmitoyltransferase-1 | - |
dc.subject | Etomoxir | - |
dc.title | Inhibition of long-chain fatty acid metabolism does not affect platelet aggregation responses | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0014-2999(98)00527-5 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, J. [0000-0001-6883-0703] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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