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https://hdl.handle.net/2440/88481
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Type: | Journal article |
Title: | A genome-wide association meta-analysis identifies new childhood obesity loci |
Author: | Bradfield, J. Taal, H. Timpson, N. Scherag, A. Lecoeur, C. Warrington, N. Hypponen, E. Holst, C. Valcarcel, B. Thiering, E. Salem, R. Schumacher, F. Cousminer, D. Sleiman, P. Jianhua, Z. Berkowitz, R. Vimaleswaran, K. Ivonne, J. Pennell, C. Evans, D. et al. |
Citation: | Nature Genetics, 2012; 44(5):526-531 |
Publisher: | Nature Publishing Group |
Issue Date: | 2012 |
ISSN: | 1061-4036 1546-1718 |
Statement of Responsibility: | Jonathan P Bradfield ... Lyle J Palmer ... et al. for the Early Growth Genetics (EGG) Consortium |
Abstract: | Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI. |
Keywords: | Early Growth Genetics Consortium Humans Obesity Genetic Predisposition to Disease Genetic Markers Body Mass Index Case-Control Studies Polymorphism, Single Nucleotide Adolescent Adult Genome-Wide Association Study Young Adult Genetic Loci |
Rights: | © 2012 Nature America, Inc. All rights reserved. |
DOI: | 10.1038/ng.2247 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/403981 |
Published version: | http://dx.doi.org/10.1038/ng.2247 |
Appears in Collections: | Aurora harvest 2 Translational Health Science publications |
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