Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/89063
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Avery, D. | - |
dc.contributor.author | Deenick, E. | - |
dc.contributor.author | Ma, C. | - |
dc.contributor.author | Suryani, S. | - |
dc.contributor.author | Simpson, N. | - |
dc.contributor.author | Chew, G. | - |
dc.contributor.author | Chan, T. | - |
dc.contributor.author | Palendira, U. | - |
dc.contributor.author | Bustamante, J. | - |
dc.contributor.author | Boisson-Dupuis, S. | - |
dc.contributor.author | Choo, S. | - |
dc.contributor.author | Bleasel, K. | - |
dc.contributor.author | Peake, J. | - |
dc.contributor.author | King, C. | - |
dc.contributor.author | French, M. | - |
dc.contributor.author | Engelhard, D. | - |
dc.contributor.author | Al-Hajjar, S. | - |
dc.contributor.author | Al-Muhsen, S. | - |
dc.contributor.author | Magdorf, K. | - |
dc.contributor.author | Roesler, J. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of Experimental Medicine, 2010; 207(1):155-171 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.issn | 1540-9538 | - |
dc.identifier.uri | http://hdl.handle.net/2440/89063 | - |
dc.description.abstract | Engagement of cytokine receptors by specific ligands activate Janus kinase-signal transducer and activator of transcription (STAT) signaling pathways. The exact roles of STATs in human lymphocyte behavior remain incompletely defined. Interleukin (IL)-21 activates STAT1 and STAT3 and has emerged as a potent regulator of B cell differentiation. We have studied patients with inactivating mutations in STAT1 or STAT3 to dissect their contribution to B cell function in vivo and in response to IL-21 in vitro. STAT3 mutations dramatically reduced the number of functional, antigen (Ag)-specific memory B cells and abolished the ability of IL-21 to induce naive B cells to differentiate into plasma cells (PCs). This resulted from impaired activation of the molecular machinery required for PC generation. In contrast, STAT1 deficiency had no effect on memory B cell formation in vivo or IL-21-induced immunoglobulin secretion in vitro. Thus, STAT3 plays a critical role in generating effector B cells from naive precursors in humans. STAT3-activating cytokines such as IL-21 thus underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients. | - |
dc.description.statementofresponsibility | Danielle T. Avery ... Pravin Hissaria ... Melanie Wong ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Rockefeller University Press | - |
dc.rights | © 2010 Avery et al. | - |
dc.source.uri | http://dx.doi.org/10.1084/jem.20091706 | - |
dc.subject | Plasma Cells | - |
dc.subject | Humans | - |
dc.subject | Immunoglobulins | - |
dc.subject | Interleukins | - |
dc.subject | Antigens | - |
dc.subject | Signal Transduction | - |
dc.subject | Cell Differentiation | - |
dc.subject | Antibody Formation | - |
dc.subject | Immunologic Memory | - |
dc.subject | Time Factors | - |
dc.subject | STAT1 Transcription Factor | - |
dc.subject | STAT3 Transcription Factor | - |
dc.title | B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1084/jem.20091706 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.