Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/92451
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Karas, J. | - |
dc.contributor.author | Scanlon, D. | - |
dc.contributor.author | Forbes, B. | - |
dc.contributor.author | Vetter, I. | - |
dc.contributor.author | Lewis, R. | - |
dc.contributor.author | Gardiner, J. | - |
dc.contributor.author | Separovic, F. | - |
dc.contributor.author | Wade, J. | - |
dc.contributor.author | Hossain, M. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Chemistry: A European Journal, 2014; 20(31):9549-9552 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.issn | 1521-3765 | - |
dc.identifier.uri | http://hdl.handle.net/2440/92451 | - |
dc.description.abstract | Chemical synthesis of peptides can allow the option of sequential formation of multiple cysteines through exploitation of judiciously chosen regioselective thiol-protecting groups. We report the use of 2-nitroveratryl (oNv) as a new orthogonal group that can be cleaved by photolysis under ambient conditions. In combination with complementary S-pyridinesulfenyl activation, disulfide bonds are formed rapidly in situ. The preparation of Fmoc-Cys(oNv)-OH is described together with its use for the solid-phase synthesis of complex cystine-rich peptides, such as insulin. | - |
dc.description.statementofresponsibility | John A. Karas, Denis B. Scanlon, Briony E. Forbes, Irina Vetter, Richard J. Lewis, James Gardiner, Frances Separovic, John D. Wade and Mohammed A. Hossain | - |
dc.language.iso | en | - |
dc.publisher | Wiley-VCH Verlag | - |
dc.rights | © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.source.uri | http://dx.doi.org/10.1002/chem.201403574 | - |
dc.subject | cysteine-protecting groups; insulin; peptides; photochemistry; regioselectivity | - |
dc.title | 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/chem.201403574 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1023321 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1023078 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 IPAS publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.