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https://hdl.handle.net/2440/9400
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Type: | Journal article |
Title: | The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila |
Author: | Chew, S. Akdemir, F. Chen, P. Lu, W. Mills, K. Daish, T. Kumar, S. Rodriguez, A. Abrams, J. |
Citation: | Developmental Cell, 2004; 7(6):897-907 |
Publisher: | Cell Press |
Issue Date: | 2004 |
ISSN: | 1534-5807 1878-1551 |
Statement of Responsibility: | Su Kit Chew, Fatih Akdemir, Po Chen, Wan-Jin Lu, Kathryn Mills, Tasman Daish, Sharad Kumar, Antony Rodriguez and John M. Abrams |
Abstract: | Among the seven caspases encoded in the fly genome, only dronc contains a caspase recruitment domain. To assess the function of this gene in development, we produced a null mutation in dronc. Animals lacking zygotic dronc are defective for programmed cell death (PCD) and arrest as early pupae. These mutants present a range of defects, including extensive hyperplasia of hematopoietic tissues, supernumerary neuronal cells, and head involution failure. dronc genetically interacts with the Ced4/Apaf1 counterpart, Dark, and adult structures lacking dronc are disrupted for fine patterning. Furthermore, in diverse models of metabolic injury, dronc− cells are completely insensitive to induction of cell killing. These findings establish dronc as an essential regulator of cell number in development and illustrate broad requirements for this apical caspase in adaptive responses during stress-induced apoptosis. |
Keywords: | Eye Hemocytes Animals Drosophila melanogaster Caspases Drosophila Proteins Green Fluorescent Proteins RNA, Messenger Immunohistochemistry Genetic Complementation Test In Situ Nick-End Labeling Reverse Transcriptase Polymerase Chain Reaction Cell Death Apoptosis Gene Expression Regulation, Developmental Mutagenesis Body Patterning Genotype Homozygote Mutation Alleles Genome Models, Genetic Time Factors Image Processing, Computer-Assisted |
DOI: | 10.1016/j.devcel.2004.09.016 |
Published version: | http://www.developmentalcell.com/ |
Appears in Collections: | Aurora harvest Medicine publications |
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