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https://hdl.handle.net/2440/9529
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Type: | Journal article |
Title: | Structural and functional hot spots in cytokine receptors |
Author: | Bagley, C. Woodcock, J. Guthridge, M. Stomski, F. Lopez, A. |
Citation: | International Journal of Hematology, 2001; 73(3):299-307 |
Publisher: | Garden Jennings Publ Co Ltd |
Issue Date: | 2001 |
ISSN: | 0925-5710 1865-3774 |
Abstract: | The activation of cytokine receptors is a stepwise process that depends on their specific interaction with cognate cytokines, the formation of oligomeric receptor complexes, and the initiation of cytoplasmic phosphorylation events. The recent determination of the structure of extracellular domains of several cytokine receptors allows comparison of their cytokine-binding surfaces. This comparison reveals a common structural framework that supports considerable diversity and adaptability of the binding surfaces that determine both the specificity and the orientation of subunits in the active receptor complex. These regions of the cytokine receptors have been targeted for the development of specific agonists and antagonists. The physical coupling of signaling intermediates to the intracellular domains of their receptors plays a major role in determining biological responses to cytokines. In this review, we focus principally on the receptors for cytokines of the granulocyte-macrophage colony-stimulating factor (GM-CSF) family and, where appropriate, compare them with related cytokine receptors. Several paradigms are beginning to emerge that focus on the ability of the extracellular portion of the cytokine receptor to recognize the appropriate cytokine and on a phosphorylated motif in the intracellular region of the GM-CSF receptor that couples to a specific signaling pathway. |
Keywords: | Hematopoietic Stem Cells Animals Humans Phosphotyrosine Phosphoserine Granulocyte-Macrophage Colony-Stimulating Factor Interleukin-3 Receptors, Cytokine Receptors, Granulocyte-Macrophage Colony-Stimulating Factor Receptors, Interleukin-3 Receptors, Interleukin Interleukin-5 Cytokines Ligands Signal Transduction Cell Division Protein Processing, Post-Translational Amino Acid Motifs Protein Conformation Structure-Activity Relationship Phosphorylation Models, Molecular Receptors, Interleukin-5 Phosphatidylinositol 3-Kinases |
DOI: | 10.1007/bf02981954 |
Published version: | http://dx.doi.org/10.1007/bf02981954 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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