Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9637
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Effect of cisapride on gastric emptying in premature infants with feed intolerance |
Author: | Barnett, C. Omari, T. Davidson, G. Goodchild, L. Lontis, R. Dent, J. Haslam, R. |
Citation: | Journal of Paediatrics and Child Health, 2001; 37(6):559-563 |
Publisher: | Blackwell Science Asia |
Issue Date: | 2001 |
ISSN: | 1034-4810 1440-1754 |
Abstract: | <h4>Objective</h4>To assess the effect of cisapride on gastric emptying and gastro-oesophageal reflux (GOR) symptoms in preterm infants with feed intolerance.<h4>Methods</h4>Sixteen preterm infants (gestational age 24-35 weeks) with feed intolerance were enrolled in the study. Infants were randomized to receive 7 days of cisapride 0.2 mg/kg four times a day, immediately followed by 7 days of placebo or vice versa. Gastric emptying was measured using the [13C]-octanoic acid breath test prior to study entry and repeated on day 5, 6 or 7 after randomization and 5, 6 or 7 days after crossover. The symptoms of GOR were monitored during the study period using a standardized reflux chart. Weight was recorded daily.<h4>Results</h4>There was no change in gastric emptying in infants prescribed cisapride (gastric half-emptying time (t1/2) 31.9 +/- 4.7 vs 34.2 +/- 3.9 min for placebo vs cisapride, respectively; P = 0.65). Infants on cisapride had slower growth and there was no change in reflux symptoms.<h4>Conclusions</h4>The use of cisapride in preterm infants with feed intolerance cannot be recommended. |
Keywords: | Humans Infant, Premature, Diseases Cisapride Gastrointestinal Agents Breath Tests Treatment Outcome Enteral Nutrition Drug Administration Schedule Probability Follow-Up Studies Cross-Over Studies Feeding and Eating Disorders of Childhood Gastric Emptying Dose-Response Relationship, Drug Reference Values Infant, Newborn Female Male |
DOI: | 10.1046/j.1440-1754.2001.00705.x |
Published version: | http://dx.doi.org/10.1046/j.1440-1754.2001.00705.x |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.