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https://hdl.handle.net/2440/97649
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Type: | Journal article |
Title: | Origins and functional evolution of Y chromosomes across mammals |
Author: | Cortez, D. Marin, R. Toledo-Flores, D. Froidevaux, L. Liechti, A. Waters, P. Gruetzner, F. Kaessmann, H. |
Citation: | Nature, 2014; 508(7497):488-493 |
Publisher: | Nature Publishing Group |
Issue Date: | 2014 |
ISSN: | 0028-0836 1476-4687 |
Statement of Responsibility: | Diego Cortez, Ray Marin, Deborah Toledo-Flores, Laure Froidevaux, Ange, lica Liechti, Paul D. Waters, Frank Grützner & Henrik Kaessmann |
Abstract: | Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representative mammals on the basis of high-throughput genome and transcriptome sequencing. We uncover three independent sex chromosome originations in mammals and birds (the outgroup). The original placental and marsupial (therian) Y, containing the sex-determining gene SRY, emerged in the therian ancestor approximately 180 million years ago, in parallel with the first of five monotreme Y chromosomes, carrying the probable sex-determining gene AMH. The avian W chromosome arose approximately 140 million years ago in the bird ancestor. The small Y/W gene repertoires, enriched in regulatory functions, were rapidly defined following stratification (recombination arrest) and erosion events and have remained considerably stable. Despite expression decreases in therians, Y/W genes show notable conservation of proto-sex chromosome expression patterns, although various Y genes evolved testis-specificities through differential regulatory decay. Thus, although some genes evolved novel functions through spatial/temporal expression shifts, most Y genes probably endured, at least initially, because of dosage constraints. |
Keywords: | Testis |
Description: | Published online 23 April 2014 |
Rights: | ©2014 Macmillan Publishers Limited. All rights reserved |
DOI: | 10.1038/nature13151 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1038/nature13151 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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