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https://hdl.handle.net/2440/9827
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Type: | Journal article |
Title: | Loss of red cell A, B, and H antigens is frequent in myeloid malignancies |
Author: | Bianco-Miotto, T. Farmer, B. Sage, R. Dobrovic, A. |
Citation: | Blood, 2001; 97(11):3633-3639 |
Publisher: | Amer Soc Hematology |
Issue Date: | 2001 |
ISSN: | 0006-4971 1528-0020 |
Statement of Responsibility: | Tina Bianco, Belinda J. Farmer, Robert E. Sage, and Alexander Dobrovic |
Abstract: | Loss of A, B, and H antigens from the surface of red blood cells has been a recurrent observation in patients with hematologic malignancy, particularly those malignancies in which the myeloid lineage is involved. To better understand this phenomenon, a 2-color flow cytometric method was developed to determine quantitative and qualitative alterations of A, B, and H antigens in patients with myeloid malignancies. Characteristic patterns, dependent on the genotype, were seen for healthy individuals from each of the blood groups. Fifty-five percent (16/29) of patients of blood group A, B, or AB had a proportion of red cells with decreased expression of A or B antigens compared with no changes in 127 healthy A, B, and AB individuals. In most cases, the changes were not detected by routine serologic typing. The loss of A or B antigens was the primary change in 28% (8/29) of patients. In 17% (5/29) of patients, loss of A or B antigens was an indirect consequence of loss of the precursor H antigen. Alterations involving both the H and the A or B antigens were seen in 10% (3/29) of patients. Loss of H was also detected in 21% (6/28) of group O patients whereas none of 51 healthy O individuals showed changes. Alterations of ABO antigens can now be considered a common event in myeloid malignancy. |
Keywords: | Erythrocytes Humans Myelodysplastic Syndromes Myeloproliferative Disorders ABO Blood-Group System Flow Cytometry Genotype Adult Leukemia, Myeloid, Acute |
Description: | © 2001 by The American Society of Hematology |
DOI: | 10.1182/blood.V97.11.3633 |
Published version: | http://bloodjournal.hematologylibrary.org/cgi/content/abstract/97/11/3633 |
Appears in Collections: | Aurora harvest Medicine publications |
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