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https://hdl.handle.net/2440/99759
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dc.contributor.author | Edwards, C. | - |
dc.contributor.author | Mukherjee, S. | - |
dc.contributor.author | Simpson, L. | - |
dc.contributor.author | Palmer, L. | - |
dc.contributor.author | Almeida, O. | - |
dc.contributor.author | Hillman, D. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The Journal of Clinical Sleep Medicine, 2015; 11(9):1029-1038 | - |
dc.identifier.issn | 1550-9389 | - |
dc.identifier.issn | 1550-9397 | - |
dc.identifier.uri | http://hdl.handle.net/2440/99759 | - |
dc.description.abstract | Study Objectives: To determine prevalence of depressive symptoms in obstructive sleep apnea (OSA) and the impact of OSA treatment on depression scores. Methods: Consecutive new patients referred for investigation of suspected OSA were approached. Consenting patients completed a patient health questionnaire (PHQ-9) for depressive symptoms when attending for laboratory polysomnography. Those with moderate/severe (apneahypopnea index [AHI] ≥ 15 events/h) and/or symptomatic mild OSA (AHI 5–14.99 events/h) were offered continuous positive airway pressure (CPAP) therapy. PHQ-9 was repeated after 3 months of CPAP with compliance recorded. Of a maximum PHQ-9 score of 27, a cut point ≥ 10 (PHQ-9 ≥ 10) was used to indicate presence of clinically signifi cant depressive symptoms. Results: A total of 426 participants (243 males) were recruited. Mean ± standard deviation body mass index (BMI) was 32.1 ± 7.1 kg/m2 and AHI 33.6 ± 28.9 events/h. PHQ-9 was 10.5 ± 6.1 and independently related to AHI (p < 0.001) and BMI (p < 0.001). In those without OSA, PHQ-9 ≥ 10 was more common in women, but no gender difference was evident with OSA. Of 293 patients offered CPAP, 228 were compliant (mean nightly use > 5 h) over 3 months of therapy. In them, with therapy, AHI decreased from 46.7 ± 27.4 to 6.5 ± 1.6 events/h, PHQ-9 from 11.3 ± 6.1 to 3.7 ± 2.9 and PHQ-9 ≥ 10 from 74.6% to 3.9% (p < 0.001 in each case). Magnitude of change in PHQ-9 was similar in men and women. Antidepressant use was constant throughout. Conclusions: Depressive symptoms are common in OSA and related to its severity. They improve markedly with CPAP, implying a relationship to untreated OSA. | - |
dc.description.statementofresponsibility | Cass Edwards, Sutapa Mukherjee, Laila Simpson, Lyle J. Palmer, Osvaldo P. Almeida, David R. Hillman | - |
dc.language.iso | en | - |
dc.publisher | American Academy of Sleep Medicine | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.5664/jcsm.5020 | - |
dc.subject | patient health questionnaire; depression; depressive symptoms; obstructive sleep apnea; continuous positive airway pressure | - |
dc.title | Depressive symptoms before and after treatment of obstructive sleep apnea in men and women | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.5664/jcsm.5020 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1031575 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Palmer, L. [0000-0002-1628-3055] | - |
Appears in Collections: | Aurora harvest 7 Translational Health Science publications |
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