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https://hdl.handle.net/2440/28073
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DC Field | Value | Language |
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dc.contributor.author | Munckhof, W. | - |
dc.contributor.author | Giles, C. | - |
dc.contributor.author | Turnidge, J. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Journal of Antimicrobial Chemotherapy, 2001; 47(6):879-883 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.issn | 1460-2091 | - |
dc.identifier.uri | http://hdl.handle.net/2440/28073 | - |
dc.description.abstract | The in vitro post-antibiotic effects (PAEs) of eight different concentrations of linezolid against Gram-positive cocci were investigated and the results analysed using the sigmoid E(max) model for mathematically modelling the PAE. Mean maximal linezolid PAEs against strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Enterococcus faecium and Streptococcus pneumoniae were 2.2, 1.8, 2.8, 2.0 and 3.0 h, respectively. Resistance to methicillin (for the staphylococci), vancomycin (for the enterococci) and penicillin (for the pneumococci) had no effect on the duration of the PAE. Results of PAE testing support twice-daily dosing of linezolid in humans. | - |
dc.language.iso | en | - |
dc.publisher | Oxford Univ Press | - |
dc.source.uri | http://dx.doi.org/10.1093/jac/47.6.879 | - |
dc.subject | Humans | - |
dc.subject | Gram-Positive Bacteria | - |
dc.subject | Staphylococcus aureus | - |
dc.subject | Staphylococcus epidermidis | - |
dc.subject | Enterococcus faecalis | - |
dc.subject | Enterococcus faecium | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Acetamides | - |
dc.subject | Oxazolidinones | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Microbial Sensitivity Tests | - |
dc.subject | Cell Division | - |
dc.subject | Linezolid | - |
dc.title | Post-antibiotic growth suppression of linezolid against Gram-positive bacteria | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/jac/47.6.879 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Turnidge, J. [0000-0003-4240-5578] | - |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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