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https://hdl.handle.net/2440/28073
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Type: | Journal article |
Title: | Post-antibiotic growth suppression of linezolid against Gram-positive bacteria |
Author: | Munckhof, W. Giles, C. Turnidge, J. |
Citation: | Journal of Antimicrobial Chemotherapy, 2001; 47(6):879-883 |
Publisher: | Oxford Univ Press |
Issue Date: | 2001 |
ISSN: | 0305-7453 1460-2091 |
Abstract: | The in vitro post-antibiotic effects (PAEs) of eight different concentrations of linezolid against Gram-positive cocci were investigated and the results analysed using the sigmoid E(max) model for mathematically modelling the PAE. Mean maximal linezolid PAEs against strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Enterococcus faecium and Streptococcus pneumoniae were 2.2, 1.8, 2.8, 2.0 and 3.0 h, respectively. Resistance to methicillin (for the staphylococci), vancomycin (for the enterococci) and penicillin (for the pneumococci) had no effect on the duration of the PAE. Results of PAE testing support twice-daily dosing of linezolid in humans. |
Keywords: | Humans Gram-Positive Bacteria Staphylococcus aureus Staphylococcus epidermidis Enterococcus faecalis Enterococcus faecium Streptococcus pneumoniae Acetamides Oxazolidinones Anti-Bacterial Agents Microbial Sensitivity Tests Cell Division Linezolid |
DOI: | 10.1093/jac/47.6.879 |
Published version: | http://dx.doi.org/10.1093/jac/47.6.879 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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