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https://hdl.handle.net/2440/3102
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Type: | Journal article |
Title: | A functional autoantibody in narcolepsy |
Author: | Smith, A. Jackson, M. Neufing, P. McEvoy, R. Gordon, T. |
Citation: | The Lancet, 2004; 364(9451):2122-2124 |
Publisher: | Lancet Ltd |
Issue Date: | 2004 |
ISSN: | 0140-6736 1474-547X |
Abstract: | Narcolepsy is widely believed to have an autoimmune basis, but conventional immunological approaches have failed to detect a serum autoantibody marker. Since cholinergic hyperactivity is a feature of narcolepsy-cataplexy, we transferred IgG from nine patients with narcolepsy and nine healthy controls to mice and assessed the effect on smooth muscle contractile responses to cholinergic stimulation. IgG from all narcolepsy patients significantly enhanced bladder contractile responses to the muscarinic agonist carbachol and to neuronally released acetylcholine compared with control IgG (p<0.0001), whereas contraction of the sympathetically innervated vas deferens was unaltered. Our findings provide direct evidence for the autoimmune hypothesis of narcolepsy. |
Keywords: | Muscle, Smooth Parasympathetic Nervous System Animals Mice, Inbred BALB C Humans Mice Narcolepsy Carbachol Immunoglobulin G Membrane Glycoproteins Cholinergic Agonists Autoantibodies HLA-DQ Antigens Synaptic Transmission Muscle Contraction Adult Aged Middle Aged Female Male HLA-DQ beta-Chains In Vitro Techniques |
DOI: | 10.1016/S0140-6736(04)17553-3 |
Published version: | http://dx.doi.org/10.1016/s0140-6736(04)17553-3 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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