Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/35564
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Cardiac changes during arousals from non-REM sleep in healthy volunteers |
Author: | Nalivaiko, E. Catcheside, P. Adams, A. Jordan, A. Eckert, D. McEvoy, R. |
Citation: | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2007; 292(3):R1320-R1327 |
Publisher: | Amer Physiological Soc |
Issue Date: | 2007 |
ISSN: | 0363-6119 1522-1490 |
Abstract: | Our aim was to evaluate cardiac changes evoked by spontaneous and sound-induced arousals from sleep. Cardiac responses to spontaneous and auditory-induced arousals were recorded during overnight sleep studies in 28 young healthy subjects (14 males, 14 females) during non-rapid eye movement sleep. Computerized analysis was applied to assess beat-to-beat changes in heart rate, atrio-ventricular conductance, and ventricular repolarization from 30 s before to 60 s after the auditory tone. During both types of arousals, the most consistent change was the increase in the heart rate (in 62% of spontaneous and in 89% of sound-induced arousals). This was accompanied by an increase or no change in PR interval and by a decrease or no change in QT interval. The magnitude of all cardiac changes was significantly higher for tone-induced vs. spontaneous arousals (mean +/- SD for heart rate: +9 +/- 8 vs. +13 +/- 9 beats per min; for PR prolongation: 14 +/- 16 vs. 24 +/- 22 ms; for QT shortening: -12 +/- 6 vs. -20 +/- 9 ms). The prevalence of transient tachycardia and PR prolongation was also significantly higher for tone-induced vs. spontaneous arousals (tachycardia: 85% vs. 57% of arousals, P < 0.001; PR prolongation: 51% vs. 25% of arousals, P < 0.001). All cardiac responses were short-lasting (10-15 s). We conclude that cardiac pacemaker region, conducting system, and ventricular myocardium may be under independent neural control. Prolongation of atrio-ventricular delay may serve to increase ventricular filling during arousal from sleep. Whether prolonged atrio-ventricular conductance associated with increased sympathetic outflow to the ventricular myocardium contributes to arrhythmogenesis during sudden arousal from sleep remains to be evaluated. |
Keywords: | Atrioventricular Node Humans Tachycardia Electrocardiography Electrooculography Electromyography Acoustic Stimulation Arousal Sleep Sleep Stages Heart Rate Time Factors Adult Female Male |
DOI: | 10.1152/ajpregu.00642.2006 |
Published version: | http://dx.doi.org/10.1152/ajpregu.00642.2006 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.