Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/43410
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DC Field | Value | Language |
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dc.contributor.author | Zhang, Q. | - |
dc.contributor.author | Bagrade, L. | - |
dc.contributor.author | Bernatoniene, J. | - |
dc.contributor.author | Clarke, E. | - |
dc.contributor.author | Paton, J. | - |
dc.contributor.author | Mitchell, T. | - |
dc.contributor.author | Nunez, D. | - |
dc.contributor.author | Finn, A. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Infectious Diseases, 2007; 195(8):1194-1202 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.uri | http://hdl.handle.net/2440/43410 | - |
dc.description | © 2007 by the Infectious Diseases Society of America. All rights reserved. | - |
dc.description.abstract | <h4>Background</h4>Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.<h4>Methods</h4>CD4 T cell proliferative responses to the pneumococcal proteins pneumolysin (Ply), Ply toxoid (F433), and choline-binding protein A were investigated in peripheral blood mononuclear cells (PBMCs) and adenoidal mononuclear cells (MNCs) obtained from children undergoing adenoidectomy.<h4>Results</h4>Ply and F433 induce significant proliferation of CD4 T cells in both PBMCs and adenoidal MNCs, and both memory and naive phenotypes of CD4 T cells proliferated after stimulation. In PBMCs, CD4 T cell proliferation induced by Ply and F433, which was associated with increased production of interferon (IFN)- gamma and tumor necrosis factor (TNF)- alpha , was significantly lower in children who were culture positive for pneumococcus than in those who were culture negative for pneumococcus (P<.05). Between groups, no such difference was observed in adenoidal MNC CD4 T cell proliferation, which was associated with production of IFN- gamma and interleukin (IL)-10. The CD4 T cell proliferation induced by Ply and F433 was inhibited by antibodies to Toll-like receptor 4.<h4>Conclusion</h4>These data suggest that Ply induces CD4 T cell proliferative responses with production of IFN- gamma and TNF- alpha in PBMCs or of IFN- gamma and IL-10 in adenoidal MNCs, which may be important in modulating pneumococcal carriage in children. | - |
dc.description.statementofresponsibility | Qibo Zhang, Linda Bagrade, Jolanta Bernatoniene, Ed Clarke, James C. Paton, Tim J. Mitchell, Desmond A. Nunez, and Adam Finn | - |
dc.language.iso | en | - |
dc.publisher | Univ Chicago Press | - |
dc.source.uri | http://www.journals.uchicago.edu/doi/abs/10.1086/512617 | - |
dc.subject | Nasopharynx | - |
dc.subject | CD4-Positive T-Lymphocytes | - |
dc.subject | Cells, Cultured | - |
dc.subject | Humans | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Pneumococcal Infections | - |
dc.subject | Tumor Necrosis Factor-alpha | - |
dc.subject | Bacterial Proteins | - |
dc.subject | Streptolysins | - |
dc.subject | Antibodies, Bacterial | - |
dc.subject | Carrier State | - |
dc.subject | Cell Proliferation | - |
dc.subject | Time Factors | - |
dc.subject | Child | - |
dc.subject | Child, Preschool | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Toll-Like Receptors | - |
dc.subject | Interferon-gamma | - |
dc.title | Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1086/512617 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Paton, J. [0000-0001-9807-5278] | - |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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